High cholesterol and triglycerides are silent health threats, often going unnoticed until they trigger cardiovascular issues. While statins and fibrates are common treatments, they can bring side effects or may not be suitable for everyone. Nattokinase (NK)—a natural enzyme from fermented soybeans—offers a promising, well-tolerated alternative.

How Nattokinase Regulates Blood Lipids

According to a comprehensive review published in the Nutrients journal (Wei et al., 2025) and supported by several clinical studies, nattokinase (NK) exerts its lipid-lowering and atherosclerosis-preventing effects through multiple mechanisms:

✅ Promotes lipolysis: Activates hormone-sensitive lipase (HSL) to facilitate the breakdown of triglycerides within adipocytes.

✅ Regulates lipoprotein metabolism: Enhances the activity of lipoprotein lipase (LPL), aiding in the breakdown of VLDL and chylomicrons (CM) in the bloodstream, thereby reducing triglyceride (TG) levels.

✅ Inhibits cholesterol synthesis: Decreases the activity of hepatic HMG-CoA reductase, limiting cholesterol production and stabilizing lipid profiles.

✅ Antithrombotic effects: Dissolves blood clots and promotes circulation, indirectly reducing vascular occlusion risk.

This multi-targeted approach makes nattokinase a natural and versatile tool for supporting healthy blood lipid levels.

Proven Clinical Benefits

Studies have shown:

📍8 weeks: TC ↓10%, TG ↓12%, LDL-C ↓11%, HDL-C ↑8%

📍12 months: Even greater reductions and improved artery health, with plaque area ↓36% and intima-media thickness ↓21.7%

Why Choose NK Over Traditional Medications?

✔️ Natural and gentle—ideal for long-term use

✔️ Supports those intolerant to statins or fibrates

✔️ Synergistic with lifestyle, red yeast rice, fish oil for comprehensive heart support

Smart Tips for Choosing NK

🔍 Look for high activity (20,000 FU/g+) and trusted brands

🔍 Check clear labeling of enzyme activity and purity

🔍 Pair NK with healthy eating and exercise for best results

Conclusion: A Modern, Natural Ally

Nattokinase is a proven, natural tool for blood lipid management—safe, effective, and rooted in traditional fermentation wisdom.

👉 Explore our high-potency NK supplements today and protect your heart naturally.

References

Wei et al., “Research Progress of Nattokinase in Reducing Blood Lipid.”, 2025 (doi: https://doi.org/10.3390/nu17111784)