Endothelial inflammation is a root cause of many cardiovascular diseases, such as atherosclerosis. A recent 2024 in-vitro study has shed light on how nattokinase (NK)—the natural enzyme from fermented soybeans (natto)—can reduce vascular inflammation at the genetic and cellular level.
How Nattokinase Works Against Inflammation
Instead of long explanations, here’s a clear breakdown:
| Nattokinase Action | Effect on Blood Vessels |
| Activates SRF gene | Helps cells survive & maintain vascular health |
| Activates THBS1 gene | Enhances autophagy (“cell self-cleaning”) |
| Suppresses NLRP3 inflammasome | Lowers harmful inflammation signals |
| Inhibits necroptosis | Prevents unnecessary cell death in arteries |
👉 In simple terms: Nattokinase boosts protective genes while calming down harmful pathways.
What the Study Found
✅ In-vitro experiments confirmed that NK activates SRF & THBS1 while suppressing inflammation pathways.
✅ Mouse models showed reduced vascular inflammation and healthier arteries.
✅ This means NK could slow down plaque build-up and protect arteries from long-term damage.
Key Health Benefits of Nattokinase
Beyond inflammation, nattokinase has multi-dimensional cardiovascular benefits:
| Benefit | Why It Matters |
| Fibrinolytic (clot-dissolving) | Helps keep blood flowing smoothly |
| Antihypertensive (blood pressure support) | Promotes vascular balance |
| Lipid-lowering | Supports healthy cholesterol levels |
| Supports healthy cholesterol levels | Anti-inflammatory |
✅ All-in-one heart support: Unlike single-pathway drugs, nattokinase works across multiple protective mechanisms.
Why This Matters for You
✅ Nattokinase is a natural, food-derived enzyme with a strong safety record.
✅ It could be a valuable supplement to support vascular health alongside lifestyle changes and medical guidance.
✅ Regular supplementation may help reduce inflammation, support circulation, and protect the heart long term.
FAQ
Q: Can I take nattokinase with other supplements like Omega-3 or CoQ10?
A: Yes. Nattokinase often works synergistically with Omega-3 fatty acids and CoQ10 to support cardiovascular health. Still, consult your healthcare provider if you’re on medication.
👉 Read more: Nattokinase vs. Omega-3 & CoQ10: Which Wins for Heart Health?
Q: Does nattokinase also help with cholesterol management?
A: Yes. Research shows that nattokinase may support lipid regulation and cholesterol balance, adding another layer of cardiovascular protection.
👉 Read more: High Cholesterol: A Silent Threat and the Power of Natural Solutions
Q: Does nattokinase have benefits beyond heart health?
A: Yes. Recent studies suggest nattokinase may also help break down microclots linked to Long COVID and brain fog, supporting circulation and reducing chronic inflammation.
👉 Read more: Nattokinase Dissolves Long-COVID Microclots: New Study
References
Chiu et al., “Cerebral hemodynamics of the aging brain: risk of Alzheimer disease and benefit of aerobic exercise.”, 2024 (doi: https://doi.org/10.1016/j.ijbiomac.2024.131779)
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